Meanwhile, dopamine must be released to stimulate the pe.nis, while acetylcholine must be present to keep the “excitement” level high. Nitric oxide, a signaling chemical, must also appear in order to provide the proper signaling between the brain and the pe.nis for a healthy ere.ction. Over mas.turbation depletes all of these neurochemicals.
Lowered dopamine requires more stimulation to stay “hard”, while decreased acetylcholine levels ruin the flow of blood to maintain an ere.ction. Depleted nitric oxide levels lead to a decrease in communication between the brain and pe.nis.